An Oxford, or serial, comma is the last comma in a list; it goes before the word "and."
Technically, it's grammatically optional in American English.
However, depending on the list you are writing out, omitting it can lead to some confusion.
A Reddit user found what could be the best three sentence arguments in existence for the use of the Oxford comma:
It's likely the book is dedicated to the author's parents, Ayn Rand, and also God — but then again, it could be that the author's parents are named Ayn Rand and God.
UPDATE: The source of the image on Reddit seems to be twitter user @alex_macdonald.
Reached by email, MacDonald told BI that the photo is of a page from Steven Pinker's "The Sense of Style." However, he added, "I have seen all of the sentences before over the years (I don't think he came up with them)."
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